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Variations in White Cell Morphology - Granulocytes

Marjorie A. Spahn, MT (ASCP); Barbara Minderman, MT (ASCP)

This course covers all aspects of white blood cell morphology, including identifying changes in morphology in granulocytes. Addresses barr bodies, Dohle bodies, Auer rods, vacuoles, hypersegmented granulocytes, and hyposegmented granulocytes. Excellent as a refresher or for clinical laboratory science students.

Continuing Education (CE) Credits

P.A.C.E. Contact Hours: 3 hour(s)
Florida CE: General (Clinical Chemistry/UA/Toxicology): 1 hour(s)

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Variations in White Cell Morphology - Granulocytes Objectives

Explain the importance of IDENTIFYING changes in WHITE CELL MORPHOLOGY in GRANULOCYTES.
Define, describe and explain the relationship of BARR BODIES to ABNORMAL MORPHOLOGY.
Discuss NUCLEAR HYPERSEGMENTATION and HYPOSEGMENTATION, with respect to:
- definition
- appearance
- composition
- significance
Discuss NUCLEAR HYPERSEGMENTATION and HYPOSEGMENTATION, with respect to:
- HYPERSEGMENTED GRANULOCYTES
- HYPOSEGMENTED GRANULOCYTES
Be able to identify each of the following CYTOPLASMIC variations:

Variations in White Cell Morphology - Granulocytes Outline

Introduction

Variations in MORPHOLOGY
Importance of Recognition
Match the following:
All of the following are important reasons to identify cell changes EXCEPT:

NUCLEAR Variations

Section Overview
HYPERSEGMENTATION
Conditions Associated with HYPERSEGMENTED NEUTROPHILS
HYPERSEGMENTED NEUTROPHIL
Another Example of a HYPERSEGMENTED NEUTROPHIL
A Normally SEGMENTED NEUTROPHIL
HYPOSEGMENTATION of Neutrophils
Conditions Associated with HYPOSEGMENTED NEUTROPHILS
PELGER-HUET Anomaly
PELGER-HUET Anomaly Does Not Affect PHAGOCYTOSIS.
Normal Band Forms vs. PELGER-HUET Bands
BILOBED Neutrophil
SINGLE-LOBED PELGER-HUET Cells
DeGENErate Neutrophils in EDTA BLOOD
PELGER-HUET Cells
PELGER-HUET Cells
BARR BODY
BARR BODIES may be Normal or PATHOLOGICAL
BARR BODY
Another BARR BODY
Which of the following statements is true for HYPERSEGMENTED NEUTROPHILS? (Choose ALL of the correct answers)
Which of the following are seen in PELGER-HUET anomaly? (Choose ALL of the correct answers)
Choose ALL of the answers that correctly complete the following statement: BARR BODIES are important to recognize because they
Which of the following best describes a BARR BODY?
HYPOSEGMENTED NEUTROPHILS are classified as either PATHOLOGICAL or NONPATHOLOGICAL.
HYPERSEGMENTED NEUTROPHILS are classified as REACTIVE.
BARR BODIES are classified as PATHOLOGICAL, NONPATHOLOGICAL, and REACTIVE.

CYTOPLASMIC Variations

CYTOPLASMIC Variations
DOHLE BODIES
More on DOHLE BODIES
MAY-HEGGLIN Bodies
More on MAY-HEGGLIN
DOHLE BODY
Unusually Darkly Staining DOHLE BODIES
MAY-HEGGLIN Anomaly
MAY-HEGGLIN Like INCLUSION
AUER RODS
Two Blasts
Two AUER RODS
One AUER ROD
CYTOPLASMIC VACUOLATION
CYTOPLASMIC VACUOLATION
Smaller VACUOLES
TOXIC GRANULATION
Neutrophil with Normal GRANULATION
BAND NEUTROPHIL Showing TOXIC GRANULATION
Another Example of TOXIC GRANULATION
DOHLE BODIES and TOXIC GRANULATION
Classification
Inherited Anomalies
CHEDIAK-HIGASHI
ALBINISM
GRANULES in CHEDIAK-HIGASHI SYNDROME versus TOXIC GRANULATION
Neutrophil with CHEDIAK-HIGASHI
Neutrophil with CHEDIAK-HIGASHI
TOXIC GRANULATION
LYMPHOCYTE with CHEDIAK-HIGASHI
ALDER-REILLY Anomaly (ALDER's Anomaly)
ALDER-REILLY Neutrophil
ALDER-REILLY Anomaly
Which of the following INCLUSIONS have a similar appearance on a WRIGHT's stained smear?
A VACUOLE may contain:
The INCLUSIONS that can be of DIAGNOSTIC significance when seen in the CYTOPLASM of MYELOBLASTS are:
TOXIC GRANULATION is seen most frequently in:
The INCLUSIONS that are frequently seen on the same slide with TOXIC GRANULATION include: (Choose ALL of the correct answers)
Match each of the following. Answers may be used more than once or not at all.
Match each of the following. Answers may be used more than once or not at all.
AUER RODS are significant when they are seen in the CYTOPLASM of blast cells because they are DIAGNOSTIC for:
CHEDIAK-HIGASHI is characterized by:
ALDER-REILLY is characterized by:
Which MORPHOLOGIC term describes this slide?
Which MORPHOLOGIC term describes this slide?
Which MORPHOLOGIC term describes this slide?
Which MORPHOLOGIC term describes this slide?
Which MORPHOLOGIC term describes this slide?
Which MORPHOLOGIC term describes this slide?

Variations in White Cell Morphology - Granulocytes Keywords

Click on a term below to see its use in this Variations in White Cell Morphology - Granulocytes course and other available MediaLab courses.

granulation (31 occurances)
toxic (27 occurances)
cytoplasm (26 occurances)
auer rod (25 occurances)
dohle bodies (21 occurances)
chediak-higashi (18 occurances)
vacuoles (18 occurances)
granules (17 occurances)
pathological (17 occurances)
nucleus (15 occurances)
may-hegglin (15 occurances)
morphological (15 occurances)
alder-reilly (15 occurances)
infection (12 occurances)
pelger-huet (11 occurances)
bacteria (11 occurances)
barr bodies (11 occurances)
body (10 occurances)
abnormal (10 occurances)
nonpathological (10 occurances)
reactive (10 occurances)
lymphocyte (9 occurances)
hypersegmented neutrophil (9 occurances)
inclusion (9 occurances)
hyposegmented (7 occurances)
morphologic (7 occurances)
platelet (7 occurances)
nuclear (6 occurances)
hypersegmented (6 occurances)
blood (6 occurances)
chromatin (6 occurances)
diagnosis (6 occurances)
dohle body (5 occurances)
granulocyte (5 occurances)
bilobed (5 occurances)
barr body (5 occurances)
azurophilic (5 occurances)
hyposegmented neutrophil (5 occurances)
monocyte (5 occurances)
syndrome (5 occurances)
stimulus (4 occurances)
morphology (4 occurances)
hyposegmentation (4 occurances)
autosomal (4 occurances)
basophil (4 occurances)
chemotherapy (4 occurances)
cytoplasmic (4 occurances)
eosinophil (4 occurances)
drug (4 occurances)
dna (4 occurances)
endoplasmic (3 occurances)
hypersegmentation (3 occurances)
chromosome (3 occurances)
bacterial (3 occurances)
identification (3 occurances)
leukemia (3 occurances)
myeloblast (3 occurances)
reticulum (3 occurances)
pyknotic (3 occurances)
wright (3 occurances)
white cell morphology (2 occurances)
virus (2 occurances)
treatment (2 occurances)
tumor (2 occurances)
vacuole (2 occurances)
thrombocytopenia (2 occurances)
protein (2 occurances)
phagocytosis (2 occurances)
physician (2 occurances)
myeloid (2 occurances)
parachromatin (2 occurances)
lysosomes (2 occurances)
malignant (2 occurances)
metastasized (2 occurances)
lymphoblast (2 occurances)
lymphoblastic (2 occurances)
band neutrophil (2 occurances)
autodigestion (2 occurances)
albinism (2 occurances)
gargoylism (2 occurances)
electron (2 occurances)
cytoplasmic vacuolation (2 occurances)
diagnostic (2 occurances)
digestion (2 occurances)
disease (2 occurances)
deficiency (2 occurances)